to Hnsch's lab see that he was using a Spectra-Physics laser (even if it. This study provides a new synergistic strategy for Ca 2+-overload-based cancer therapy, as well as a strategy for anchoring photosensitizer on the cell membrane, offering broad application prospects for the treatment of lung cancer. Eventually, this new narrowband high-power laser technology was working well. Synergistically enhanced antitumor efficiency is observed in vitro and in vivo. The in vitro study shows that CMA-nPS mainly anchors on the cell membrane, and further causes membrane damage, mitochondrial dysfunction, as well as intracellular Ca 2+ overload upon light irradiation. CMA-nPS is decorated by two types of functionalized cell membranes, the azide-modified macrophage cell membrane is used to conjugate the dibenzocyclooctyne-decorated photosensitizer, and the vesicular stomatitis virus glycoprotein (VSV-G)-modified NIH3T3 cell membrane is used to guide the anchoring of photosensitizer to the lung cancer cell membrane.
To address this issue, a cell membrane-anchoring nano-photosensitizer (CMA-nPS) is constructed for inducing tumor-specific Ca 2+ overload through multistage endogenous Ca 2+ homeostasis disruption under light guidance, i.e., the extracellular Ca 2+ influx caused by cell membrane damage, followed by the intracellular Ca 2+ imbalance caused by mitochondrial dysfunction. Poor selectivity and unintended toxicity to normal organs are major challenges in calcium ion (Ca 2+) overload tumor therapy. Spectra Geospatial offers powerful, highly versatile yet ultra-rugged and reliable Global Navigation Satellite System (GNSS) positioning solutions for a wide variety of applications. Grainger is your premier industrial supplies and equipment provider with over 1.6 million products to keep you up and running.
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